1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

Base Information

• Chemical Name: 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone
• CAS No.: 1281816-29-2
• Molecular Formula: C₂₃H₂₂ClNO
• Molecular Weight: 363.887
• Mol file: 1281816-29-2.mol

Synonyms:1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

Chemical Property of 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

There total 6 articles about 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.2%

acetic anhydride (108-24-7) + 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine (133111-56-5) → 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone (1281816-29-2)

Guidance literature:

With aluminum (III) chloride; In diethyl ether; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

5.5-dimethyl-1,3,2-dioxathiane-2-oxide (1003-85-6) → 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone (1281816-29-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 36 h / 100 °C

2.1: pyridine; thionyl chloride / 0 °C

3.1: diethyl ether / 2 h / Reflux

3.2: 3 h / Reflux

4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

5.1: aluminum (III) chloride / diethyl ether / 20 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; thionyl chloride; sodium hydrogencarbonate; In diethyl ether; ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

3,3-dimethyl-4-hydroxy butyronitrile (103804-80-4) → 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone (1281816-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; thionyl chloride / 0 °C

2.1: diethyl ether / 2 h / Reflux

2.2: 3 h / Reflux

3.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

4.1: aluminum (III) chloride / diethyl ether / 20 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; thionyl chloride; sodium hydrogencarbonate; In diethyl ether; ethanol;

DOI:10.1016/j.ejmech.2011.01.002

upstream raw materials:

5.5-dimethyl-1,3,2-dioxathiane-2-oxide

3,3-dimethyl-4-hydroxy butyronitrile

acetic anhydride

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine