3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

Base Information

Chemical Name:3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate
CAS No.:935841-08-0
Molecular Formula:C₂HF₃O₂*C₁₈H₂₃FN₂O
Molecular Weight:416.416
Hs Code.:

Synonyms:3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

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Technology Process of 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

There total 1 articles about 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935840-50-9
N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide

: 76-05-1
trifluoroacetic acid

: 935841-08-0
3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

Guidance literature:: In 1,2-dichloro-ethane; at 75 ℃; for 18h;

Reference yield:

: 935841-08-0
3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate

: 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutanecarboxylic acid ethylamide

Guidance literature:: 3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate; With hydrogen; Wilkinson's catalyst; In ethanol; at 60 ℃; for 2h; under 2327.23 Torr;

With hydrogenchloride; In water;

With sodium hydroxide; In water;