N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide

Base Information

• Chemical Name: N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide
• CAS No.: 935840-50-9
• Molecular Formula: C₁₈H₂₅FN₂O₂
• Molecular Weight: 320.407
• Mol file: 935840-50-9.mol

Synonyms:N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide

Chemical Property of N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide

There total 3 articles about N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H22FNO3 + diethylamine (109-89-7) → N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide (935840-50-9)

Guidance literature:

In methanol; at 45 ℃; for 4h;

DOI:10.1021/op300093j

Reference yield:

propan-2-yl 3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxylate → N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide (935840-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: methanol / 4 h / 45 °C

In methanol;

DOI:10.1021/op300093j

Reference yield:

C33H39F3MgN3(1-)*Li(1+) → N-ethyl-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxamide (935840-50-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; hexane / 1.67 h / 30 °C

2: methanol

3: methanol / 4 h / 45 °C

In tetrahydrofuran; methanol; hexane;

DOI:10.1021/op300093j

upstream raw materials:

diethylamine

Downstream raw materials:

3-(3-fluoro-4-pyrrolidin-1-ylmethyl-phenyl)-cyclobut-2-enecarboxylic acid ethylamide trifluoroacetate