1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea

Base Information

• Chemical Name: 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea
• CAS No.: 1416274-90-2
• Molecular Formula: C₂₃H₂₇N₇O₂S
• Molecular Weight: 465.579
• Mol file: 1416274-90-2.mol

Synonyms:1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea

Chemical Property of 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea

There total 8 articles about 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate (1416274-84-4) → 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea (1416274-90-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 50 ℃; for 48h;

DOI:10.1248/cpb.c12-00234

Reference yield:

1-phenyl-3-(4-(4-(piperazin-1-ylmethyl)thiazol-2-yl)phenyl)urea (1416274-78-6) → 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea (1416274-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

2: hydrazine hydrate / ethanol / 48 h / 50 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In ethanol;

DOI:10.1248/cpb.c12-00234

Reference yield:

4-(3-phenylureido)benzothioamide (1016869-60-5) → 1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea (1416274-90-2)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 7 h / 50 °C

2: ethanol / 2 h / 20 °C

3: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

4: hydrazine hydrate / ethanol / 48 h / 50 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.c12-00234

upstream raw materials:

4-(3-phenylureido)benzothioamide

1-(4-(4-(chloromethyl)thiazol-2-yl)phenyl)-3-phenylurea

1-phenyl-3-(4-(4-(piperazin-1-ylmethyl)thiazol-2-yl)phenyl)urea

ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate