ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Base Information

• Chemical Name: ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate
• CAS No.: 1416274-84-4
• Molecular Formula: C₂₅H₂₉N₅O₃S
• Molecular Weight: 479.603
• Mol file: 1416274-84-4.mol

Synonyms:ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Chemical Property of ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

There total 7 articles about ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

1-phenyl-3-(4-(4-(piperazin-1-ylmethyl)thiazol-2-yl)phenyl)urea (1416274-78-6) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate (1416274-84-4)

Guidance literature:

With potassium carbonate; sodium iodide; In ethanol; at 50 ℃; for 2h;

DOI:10.3390/molecules18032904

Reference yield:

4-(3-phenylureido)benzothioamide (1016869-60-5) → ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate (1416274-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 7 h / 50 °C

2: ethanol / 2 h / 20 °C

3: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

With potassium carbonate; sodium iodide; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.c12-00234

Reference yield:

1-(4-(4-(chloromethyl)thiazol-2-yl)phenyl)-3-phenylurea (1416274-72-0) → ethyl 2-(4-((2-(4-(3-phenylureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate (1416274-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 20 °C

2: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

With potassium carbonate; sodium iodide; In ethanol;

DOI:10.1248/cpb.c12-00234

upstream raw materials:

4-(3-phenylureido)benzothioamide

1-(4-(4-(chloromethyl)thiazol-2-yl)phenyl)-3-phenylurea

1-phenyl-3-(4-(4-(piperazin-1-ylmethyl)thiazol-2-yl)phenyl)urea

chloroacetic acid ethyl ester

Downstream raw materials:

1-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)-3-phenylurea