C₂₆H₂₁NO₄

Base Information

• Chemical Name: C₂₆H₂₁NO₄
• CAS No.: 133165-27-2
• Molecular Formula: C₂₆H₂₁NO₄
• Molecular Weight: 411.457
• Mol file: 133165-27-2.mol

Synonyms:C₂₆H₂₁NO₄

Chemical Property of C₂₆H₂₁NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₆H₂₁NO₄

There total 12 articles about C₂₆H₂₁NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cyclohexa-1,4-diene (1165952-92-0) + C26H19NO4 (130031-63-9) → C26H21NO4 (133165-27-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 25 ℃; for 24h;

DOI:10.1021/ja00008a045

Reference yield:

7,8,9,10-tetrahydrophenanthridine (62833-92-5) → C26H21NO4 (133165-27-2)

Guidance literature:

Multi-step reaction with 12 steps

1: 78 percent / mCPBA / CH₂Cl₂ / 1 h / 25 °C

2: 87 percent / 20 h / 100 °C

3: 100 percent / K₂CO₃ / methanol / 1 h / 25 °C

4: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5: 1.) THF, -78 degC to 0 deg C, 2.) -78 deg C to 25 deg C, 1 h

6: 85 percent / mCPBA / CH₂Cl₂ / 2 h / 25 °C

7: 100 percent / Bu₄NF / tetrahydrofuran / 3 h / 42 °C

8: 80 percent / pyridinium chlorochromate, 4-Angstroem molecular sieves / CH₂Cl₂ / 1 h / 25 °C

9: 1.) Pd(CH₃COO)2, Ph₃P, n-BuNH₂, 2.) Cu₂I₂ / 1.) C₆H₆, 25 deg C, 15 min, 2.) 25 deg C, 2 h

10: 1.) AgNO₃, 2.) KCN / 1.) H₂O, C₂H₅OH, THF, 25 deg C, 5 min, 2.) 10 min

11: 59 percent / LDA / toluene; cyclohexane / 1 h / -78 °C

12: 92 percent / p-toluenesulfonic acid / benzene / 24 h / 25 °C

With 2,6-dimethylpyridine; potassium cyanide; palladium diacetate; copper (I) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; silver nitrate; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene; benzene;

DOI:10.1021/ja00008a045

Reference yield:

7,8,9,10-tetrahydrophenanthridine N-oxide (133165-23-8) → C26H21NO4 (133165-27-2)

Guidance literature:

Multi-step reaction with 11 steps

1: 87 percent / 20 h / 100 °C

2: 100 percent / K₂CO₃ / methanol / 1 h / 25 °C

3: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

4: 1.) THF, -78 degC to 0 deg C, 2.) -78 deg C to 25 deg C, 1 h

5: 85 percent / mCPBA / CH₂Cl₂ / 2 h / 25 °C

6: 100 percent / Bu₄NF / tetrahydrofuran / 3 h / 42 °C

7: 80 percent / pyridinium chlorochromate, 4-Angstroem molecular sieves / CH₂Cl₂ / 1 h / 25 °C

8: 1.) Pd(CH₃COO)2, Ph₃P, n-BuNH₂, 2.) Cu₂I₂ / 1.) C₆H₆, 25 deg C, 15 min, 2.) 25 deg C, 2 h

9: 1.) AgNO₃, 2.) KCN / 1.) H₂O, C₂H₅OH, THF, 25 deg C, 5 min, 2.) 10 min

10: 59 percent / LDA / toluene; cyclohexane / 1 h / -78 °C

11: 92 percent / p-toluenesulfonic acid / benzene / 24 h / 25 °C

With 2,6-dimethylpyridine; potassium cyanide; palladium diacetate; copper (I) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; silver nitrate; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene; benzene;

DOI:10.1021/ja00008a045

upstream raw materials:

cyclohexa-1,4-diene

C₂₆H₁₉NO₄

7,8,9,10-tetrahydrophenanthridine

7,8,9,10-tetrahydrophenanthridine N-oxide