3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

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Chemical Name:3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione
CAS No.:1631037-70-1
Molecular Formula:C₃₀H₂₂Cl₂N₄O₂S
Molecular Weight:573.502
Hs Code.:

Synonyms:3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

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Chemical Property of 3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

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Technology Process of 3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

There total 2 articles about 3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 120-72-9
indole

: 1579938-33-2
C₁₉H₁₁Cl₂N₃O₂S

: 109-64-8
1,3-dibromo-propane

: 1631037-70-1
3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

Guidance literature:: C₁₉H₁₁Cl₂N₃O₂S; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice;

indole; 1,3-dibromo-propane; With potassium hydroxide; In tetrahydrofuran; Reflux;
DOI:10.1002/ardp.201300466

Reference yield:

: 618098-88-7
C₁₆H₁₀Cl₂N₂O

: 1631037-70-1
3-(3-(1H-indol-1-yl)propyl)-5-((3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / toluene / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

2.2: Reflux

With piperidine; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1002/ardp.201300466