(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

Base Information

Chemical Name:(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
CAS No.:1313481-54-7
Molecular Formula:C₂₄H₂₈N₄O₇S
Molecular Weight:516.575
Hs Code.:

Synonyms:(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

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Chemical Property of (E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

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Technology Process of (E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

There total 5 articles about (E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1384097-71-5
(E)-4-(2,4-dimethoxybenzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

: 105-36-2
ethyl bromoacetate

: 1313481-54-7
(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

Guidance literature:: (E)-4-(2,4-dimethoxybenzylideneamino)-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione; With potassium carbonate; In acetone; for 0.5h; Reflux;

ethyl bromoacetate; In acetone; Reflux;
DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

: 31821-78-0
4-amino-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione

: 1313481-54-7
(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 2 h / Reflux

2.1: potassium carbonate / acetone / 0.5 h / Reflux

2.2: Reflux

With potassium carbonate; acetic acid; In acetone;
DOI:10.1016/j.bmcl.2012.03.023

Reference yield:

: 6178-44-5
ethyl 3,4,5-trimethoxybenzoate

: 1313481-54-7
(E)-ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 6 h / Reflux

2.1: potassium hydroxide / ethanol / 16 h / 20 °C

2.2: 3 h / Reflux

3.1: acetic acid / 2 h / Reflux

4.1: potassium carbonate / acetone / 0.5 h / Reflux

4.2: Reflux

With potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; acetone;
DOI:10.1016/j.bmcl.2012.03.023