2-Methyl-n,2-diphenylpropanamide

Base Information

• Chemical Name: 2-Methyl-n,2-diphenylpropanamide
• CAS No.: 58265-36-4
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• NSC Number: 133535
• DSSTox Substance ID: DTXSID40299890
• Nikkaji Number: J2.814.020G
• Wikidata: Q82042585
• Mol file: 58265-36-4.mol

Synonyms:2-methyl-n,2-diphenylpropanamide;58265-36-4;NSC133535;SCHEMBL4965466;DTXSID40299890;AKOS008463163;NSC-133535;AO-854/43462882

Chemical Property of 2-Methyl-n,2-diphenylpropanamide

Chemical Property:

• Vapor Pressure: 1.82E-07mmHg at 25°C
• Boiling Point: 426.1°C at 760 mmHg
• Flash Point: 258.1°C
• Density: 1.102g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 239.131014166
• Heavy Atom Count: 18
• Complexity: 273

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC=CC=C1)C(=O)NC2=CC=CC=C2

Technology Process of 2-Methyl-n,2-diphenylpropanamide

There total 20 articles about 2-Methyl-n,2-diphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

carbon monoxide (201230-82-2) + aniline hydrochloride (142-04-1,36663-09-9) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 2-methyl-N,2-diphenylpropanamide (58265-36-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 110 ℃; for 24h; under 34202.3 Torr; Reagent/catalyst; regioselective reaction; Catalytic behavior; Autoclave;

DOI:10.1021/jacs.1c03454

Reference yield: 93.0%

2-methyl-2-phenyl-propan-1-ol (2173-69-5) + aniline (62-53-3) → 2-methyl-N,2-diphenylpropanamide (58265-36-4)

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2,2-Trifluoroacetophenone; cesium acetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 80 ℃; for 24h;

DOI:10.1021/acscatal.6b02541

Reference yield: 91.0%

2-methyl-2-phenylpropionic acid (826-55-1) + aniline (62-53-3) → 2-methyl-N,2-diphenylpropanamide (58265-36-4)

Guidance literature:

With 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; In acetonitrile; at 23 ℃; for 0.666667h;

DOI:10.1021/acs.orglett.8b01591

upstream raw materials:

2,3-diphenyl-2-methylpropan-3-one oxime

5,5-dimethyl-3,4-diphenyl-4,5-dihydro-3H-[1,2,3]triazol-4-ol

1-(2-methyl-2-phenylpropanoyl)-1H-imidazole

aniline