(S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol

Base Information

• Chemical Name: (S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol
• CAS No.: 935697-12-4
• Molecular Formula: C₃₀H₃₆OSi
• Molecular Weight: 440.701
• Mol file: 935697-12-4.mol

Synonyms:(S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol

Chemical Property of (S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol

There total 1 articles about (S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorobromomethane (74-97-5) + benzaldehyde (100-52-7) + ο-methylenebicyclo<5.1.0>octane (54211-15-3,115411-11-5) + 2-(methyldiphenylsilyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (200010-86-2) → (S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol (935697-12-4) + C30H36OSi

Guidance literature:

ο-methylenebicyclo<5.1.0>octane; 2-(methyldiphenylsilyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 50 ℃; for 48h;

chlorobromomethane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

benzaldehyde; In tetrahydrofuran; hexane; at -10 - 20 ℃; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja0703170

Reference yield:

(S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol (935697-12-4) + (S)-2-methoxy-2-phenylacetic acid (26164-26-1) → C39H44O3Si

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/ja0703170

Reference yield:

(S)-3-[(1S,2S)-2-(methyldiphenylsilyl)cycloheptyl]-1-phenylbut-3-en-1-ol (935697-12-4) + (R)-methoxyphenylacetic acid (3966-32-3) → C39H44O3Si

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/ja0703170

upstream raw materials:

chlorobromomethane

benzaldehyde

ο-methylenebicyclo<5.1.0>octane

2-(methyldiphenylsilyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane