3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1613711-42-4
Molecular Formula:C₂₅H₂₆FN₃OS
Molecular Weight:435.565
Hs Code.:

Synonyms:3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

There total 5 articles about 3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1654740-12-1
C₃₂H₃₂FN₃O₃S₂

: 1613711-42-4
3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With water; potassium carbonate; In methanol; at 60 ℃;

Reference yield:

: 875639-15-9
5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1613711-42-4
3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 0.25 h / Inert atmosphere; Sealed tube

1.2: 6.25 h / 90 °C / Inert atmosphere

2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 10 h / 85 °C / Sealed tube

3.1: n-butyllithium / tetrahydrofuran / 2 h / -30 °C

4.1: potassium carbonate; water / methanol / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; water; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 762287-59-2
(3-fluoro-2-methoxyphenyl)boronic acid

: 1613711-42-4
3-(3-fluoro-2-methoxyphenyl)-5-(5-(1-(piperidin-1-yl)ethyl)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 0.25 h / Inert atmosphere; Sealed tube

1.2: 6.25 h / 90 °C / Inert atmosphere

2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 10 h / 85 °C / Sealed tube

3.1: n-butyllithium / tetrahydrofuran / 2 h / -30 °C

4.1: potassium carbonate; water / methanol / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; water; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; acetonitrile;