5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide
CAS No.:1443361-73-6
Molecular Formula:C₂₄H₁₈F₂N₂O₃
Molecular Weight:420.415
Hs Code.:

Synonyms:5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

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Chemical Property of 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

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Technology Process of 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

There total 8 articles about 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: C₁₈H₁₂ClF₂NO₃

: 62-53-3
aniline

: 1443361-73-6
5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1021/jm400540b

Reference yield:

: 1203712-03-1
5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 62-53-3
aniline

: 1443361-73-6
5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

: 1203711-96-9
ethyl 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 1443361-73-6
5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux

2.1: dichloromethane / 3.5 h / 0 °C / Inert atmosphere

2.2: 1.02 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: dichloromethane / 20 °C

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm400540b