2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Base Information

Chemical Name:2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
CAS No.:1215012-88-6
Molecular Formula:C₂₃H₃₁Cl₂F₃N₄O₂S
Molecular Weight:555.492
Hs Code.:

Synonyms:2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Chemical Property of 2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Technology Process of 2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

There total 7 articles about 2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5261-66-5
4-allyl-1-methylpiperidine

: 1215013-89-0
4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

: 1215012-88-6
2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: 4-allyl-1-methylpiperidine; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 90 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm500809c

Reference yield:

: 5261-66-5
4-allyl-1-methylpiperidine

: 1215012-88-6
2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:

Reference yield:

: 1215009-29-2
4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

: 1215012-88-6
2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / Inert atmosphere; Microwave irradiation

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.5 h / 90 °C / Inert atmosphere; Microwave irradiation

2.2: 0.5 h / 80 °C / Inert atmosphere; Microwave irradiation

With potassium carbonate; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; acetonitrile; 2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500809c