4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
• CAS No.: 1215013-89-0
• Molecular Formula: C₁₄H₁₃BrCl₂F₃N₃O₂S
• Molecular Weight: 495.147
• Mol file: 1215013-89-0.mol

Synonyms:4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Chemical Property of 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

There total 4 articles about 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,2,2-trifluoroethyl methanesulfonate (25236-64-0) + 4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide (1215009-29-2) → 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide (1215013-89-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm500809c

Reference yield:

2,2,2-trifluoroethyl methanesulfonate (25236-64-0) → 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide (1215013-89-0)

Guidance literature:

With potassium carbonate; In acetonitrile;

Reference yield:

4-bromo-2,6-dichlorobenzenesulfonyl chloride (351003-54-8) → 4-bromo-2,6-dichloro-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide (1215013-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 24 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 0.5 h / Inert atmosphere; Microwave irradiation

With pyridine; potassium carbonate; In acetonitrile;

DOI:10.1021/jm500809c

upstream raw materials:

2,2,2-trifluoroethyl methanesulfonate

4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

4-bromo-2,6-dichlorobenzenesulfonyl chloride

1,3,5-trimethyl-1H-pyrazol-4-amine

Downstream raw materials:

2,6-dichloro-4-(3-(1-methylpiperidin-4-yl)propyl)-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide