2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

Base Information

Chemical Name:2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin
CAS No.:106203-40-1
Molecular Formula:C₂₅H₂₂FNO₄S
Molecular Weight:451.518
Hs Code.:

2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenz<b,f>oxepin

Synonyms:2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

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Chemical Property of 2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

Chemical Property:

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Technology Process of 2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

There total 6 articles about 2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 106203-37-6
2-fluoro-7-methoxy-11-<β-(dimethylamino)ethylthio>dibenzoxepin

: 1885-14-9
phenyl chloroformate

: 106203-40-1
2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

Guidance literature:: With potassium carbonate; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1002/jhet.5570230155

Reference yield:

: 106203-28-5
1-Chloromethyl-2-(4-fluoro-phenoxy)-4-methoxy-benzene

: 106203-40-1
2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfoxide / 17 h / Ambient temperature

2: 67 percent / KOH / aq. ethanol / 16 h / Heating

3: 86 percent / polyphosphoric acid / 1,2-dichloro-ethane / 24 h / Heating

4: 60 percent / boron trifluoride etherate / acetic acid / 34 h / 85 °C

5: 92 percent / K₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; PPA; boron trifluoride diethyl etherate; potassium carbonate; In ethanol; dichloromethane; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570230155

Reference yield:

: 106203-27-4
[2-(4-Fluoro-phenoxy)-4-methoxy-phenyl]-methanol

: 106203-40-1
2-fluoro-7-methoxy-11-<β-(N-methyl-N-phenoxycarbonyl)ethylthio>dibenzoxepin

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / CH₂Cl₂ / 2 h / Heating

2: dimethylsulfoxide / 17 h / Ambient temperature

3: 67 percent / KOH / aq. ethanol / 16 h / Heating

4: 86 percent / polyphosphoric acid / 1,2-dichloro-ethane / 24 h / Heating

5: 60 percent / boron trifluoride etherate / acetic acid / 34 h / 85 °C

6: 92 percent / K₂CO₃ / CH₂Cl₂ / 16 h / Ambient temperature

With potassium hydroxide; thionyl chloride; PPA; boron trifluoride diethyl etherate; potassium carbonate; In ethanol; dichloromethane; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570230155