C₁₉H₂₁ClN₄O₃

Base Information

• Chemical Name: C₁₉H₂₁ClN₄O₃
• CAS No.: 1466565-98-9
• Molecular Formula: C₁₉H₂₁ClN₄O₃
• Molecular Weight: 388.854
• Mol file: 1466565-98-9.mol

Synonyms:C₁₉H₂₁ClN₄O₃

Chemical Property of C₁₉H₂₁ClN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₁ClN₄O₃

There total 7 articles about C₁₉H₂₁ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-(1-((3-chloro-2-(phenylcarbamoyl)-1H-pyrrole-1-yl)amino)-1-oxopropane-2-yl)carbamate (1466565-97-8) → C19H21ClN4O3 (1466565-98-9)

Guidance literature:

With iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole (226409-94-5) → C19H21ClN4O3 (1466565-98-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol / 2.5 h / 0 - 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol / 1.5 h / 60 °C

3.1: thionyl chloride / 0.83 h / 75 °C / Inert atmosphere

3.2: 2 h / 0 - 60 °C / Inert atmosphere

4.1: sodium hydroxide; ammonium hydroxide; sodium hypochlorite; ammonium chloride / water; ethyl acetate; tert-butyl methyl ether / 2.5 h / 0 - 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 65 h / 20 °C

6.1: triphenylphosphine; iodine; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With ammonium hydroxide; sodium hypochlorite; thionyl chloride; iodine; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide (1403941-86-5) → C19H21ClN4O3 (1466565-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 65 h / 20 °C

2: triphenylphosphine; iodine; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With iodine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-methyl-1H-pyrroline

4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole

3-chloro-1H-pyrrole-2-carboxylic acid methyl ester

3-chloro-1H-pyrrole-2-carboxylic acid

Downstream raw materials:

C₁₄H₁₃ClN₄O