1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide
CAS No.:1403941-86-5
Molecular Formula:C₁₁H₁₀ClN₃O
Molecular Weight:235.673
Hs Code.:

Synonyms:1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

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Chemical Property of 1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

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Technology Process of 1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

There total 6 articles about 1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1466565-96-7
3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

: 1403941-86-5
1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: With ammonium hydroxide; sodium hypochlorite; Aliquat 336; ammonium chloride; sodium hydroxide; In diethyl ether; tert-butyl methyl ether; water; at 0 - 20 ℃;
DOI:10.3762/bjoc.12.168

Reference yield:

: 1053658-09-5
3-chloro-1H-pyrrole-2-carboxylic acid

: 1403941-86-5
1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 0.83 h / 75 °C / Inert atmosphere

1.2: 2 h / 0 - 60 °C / Inert atmosphere

2.1: sodium hydroxide; ammonium hydroxide; sodium hypochlorite; ammonium chloride / water; ethyl acetate; tert-butyl methyl ether / 2.5 h / 0 - 20 °C

With ammonium hydroxide; sodium hypochlorite; thionyl chloride; ammonium chloride; sodium hydroxide; In tert-butyl methyl ether; water; ethyl acetate;

Reference yield:

: 872-32-2
2-methyl-1H-pyrroline

: 1403941-86-5
1-amino-3-chloro-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 0.58 h / 55 °C

2.1: methanol / 2.5 h / 0 - 20 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol / 1.5 h / 60 °C

4.1: thionyl chloride / 0.83 h / 75 °C / Inert atmosphere

4.2: 2 h / 0 - 60 °C / Inert atmosphere

5.1: sodium hydroxide; ammonium hydroxide; sodium hypochlorite; ammonium chloride / water; ethyl acetate; tert-butyl methyl ether / 2.5 h / 0 - 20 °C

With ammonium hydroxide; sodium hypochlorite; N-chloro-succinimide; thionyl chloride; ammonium chloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; ethyl acetate;