Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester

Base Information

• Chemical Name: Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester
• CAS No.: 868051-66-5
• Molecular Formula: C₅₃H₉₂O₁₀
• Molecular Weight: 889.307

Synonyms:Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester

Chemical Property of Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester

Chemical Property:

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Technology Process of Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester

There total 6 articles about Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Malonic acid 3-hydroxy-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester (868051-65-4) + 1-bromo-3-propanol (627-18-9) → Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester (868051-66-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 12h; Heating;

DOI:10.1016/j.tetlet.2005.08.038

Reference yield:

1-octadecanol (112-92-5) → Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester (868051-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / 1 h / 110 - 120 °C

2: 53 percent / N,N'-dicyclohexylcarbodiimide; DMAP; HOBT / tetrahydrofuran / 3 h

3: 72 percent / K₂CO₃; 18-crown-6 / acetone / 12 h / Heating

With dmap; 18-crown-6 ether; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetone;

DOI:10.1016/j.tetlet.2005.08.038

Reference yield:

2-((octadecyloxy)carbonyl)acetic acid (1002-31-9) → Malonic acid 3-(3-hydroxy-propoxy)-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester (868051-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / N,N'-dicyclohexylcarbodiimide; DMAP; HOBT / tetrahydrofuran / 3 h

2: 72 percent / K₂CO₃; 18-crown-6 / acetone / 12 h / Heating

With dmap; 18-crown-6 ether; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetone;

DOI:10.1016/j.tetlet.2005.08.038

upstream raw materials:

Malonic acid 3-hydroxy-5-(2-octadecyloxycarbonyl-acetoxymethyl)-benzyl ester octadecyl ester

1-bromo-3-propanol

1-octadecanol

2-((octadecyloxy)carbonyl)acetic acid

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