5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine

Base Information

• Chemical Name: 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine
• CAS No.: 685872-27-9
• Molecular Formula: C₁₆H₁₂F₄N₂S
• Molecular Weight: 340.344
• Mol file: 685872-27-9.mol

Synonyms:5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine

Chemical Property of 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine

There total 6 articles about 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ⁴-benzo[1,2,4]thiadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N'-[2,3,4,5-tetrafluoro-6-(propylthio)phenyl]benzamidine (685872-06-4) → 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ4-benzo[1,2,4]thiadiazine (685872-27-9) + N-chloro-N'-[2,3,4,5-tetrafluoro-6-(propylthio)phenyl]benzamidine (685872-29-1)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo035835h

Reference yield:

N'-[2,3,4,5-tetrafluoro-6-(propylthio)phenyl]benzamidine (685872-06-4) → 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ4-benzo[1,2,4]thiadiazine (685872-27-9)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at -78 - 20 ℃; for 25h;

DOI:10.1021/jo035835h

Reference yield:

2,3,4,5-tetrafluoroaniline (5580-80-3) → 5,6,7,8-tetrafluoro-3-phenyl-1-propyl-1λ4-benzo[1,2,4]thiadiazine (685872-27-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / Br₂

2: 38 percent / Cs₂CO₃ / dimethylformamide / 12 h / 120 °C

3: 94 percent / methanesulfonic acid / 0.5 h / 150 °C

4: NCS / CH₂Cl₂ / 25 h / -78 - 20 °C

With N-chloro-succinimide; methanesulfonic acid; bromine; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo035835h

upstream raw materials:

N'-[2,3,4,5-tetrafluoro-6-(propylthio)phenyl]benzamidine

N-chloro-N'-[2,3,4,5-tetrafluoro-6-(propylthio)phenyl]benzamidine

2,3,4,5-tetrafluoroaniline

2-bromo-3,4,5,6-tetrafluoroaniline

Downstream raw materials:

5,6,7,8-tetrafluoro-3-phenyl-4H-benzo[1,2,4]thiadiazine