5580-80-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4,5-Tetrafluoroaniline is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3,4,5-Tetrafluoroaniline serves as a key component in the production of certain pesticides and herbicides, enhancing their effectiveness in controlling pests and weeds.
Used in Dye Industry:
2,3,4,5-Tetrafluoroaniline is utilized in the creation of dyes, providing a range of vibrant colors for various applications, including textiles, plastics, and printing inks.
Used in Organic Electronics:
2,3,4,5-Tetrafluoroaniline has been studied for its potential use in organic electronics, such as in the development of organic light-emitting diodes (OLEDs) and organic solar cells, due to its electronic properties.
Used in Synthesis of Novel Materials:
As a building block, 2,3,4,5-Tetrafluoroaniline is employed in the synthesis of new materials with unique properties, expanding the horizons of material science and technology.

InChI:InChI=1/C6H3F4N/c7-2-1-3(11)5(9)6(10)4(2)8/h1H,11H2

Upstream product

• 16583-00-9 2-NH₂C₆F₄C(O)NH₂ 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 1765-42-0 2-amino-3,4,5,6-tetrafluorobenzoic acid 
• 16582-88-0 N-(2,3,4,5-tetrafluorophenyl)acetamide 
• 653-22-5 1-Acetylamino-2,3,4,5,6-pentafluorobenzen 
• 771-60-8 2,3,4,5,6-pentafluoroaniline 
• 5580-81-4 2-Brom-3,4,5,6-tetrafluor-acet-anilid 
• 16582-99-3 2-NH₂-C₆F₄CN 
• 5580-82-5 2-bromo-3,4,5,6-tetrafluoroaniline 
• 5580-79-0 2,3,4,5-tetrafluoro-1-nitrobenzene 

Downstream Products

• 1765-42-0 2-amino-3,4,5,6-tetrafluorobenzoic acid 
• 5121-89-1 1-iodo 2,3,4,5-tetrafluoro benzene 
• 5580-82-5 2-bromo-3,4,5,6-tetrafluoroaniline 
• 5280-07-9 5,6,7,8-Tetrafluoroquinoline 
• 1228813-89-5 2-iodo-3,4,5,6-tetrafluoroaniline 
• 1363411-75-9 2,3,4,5-tetrafluoro-6-(hex-1-yn-1-yl)aniline 
• 1363411-76-0 C₁₄H₇F₄N 
• 1363411-77-1 C₁₄H₁₃F₄NO₂ 
• 1380597-85-2 2-ethynyltetrafluoroaniline 
• 1422451-05-5 N,N′-bis(2,3,4,5-tetrafluorophenyl)formamidine 

Relevant academic research and scientific papers

Interaction of polyfluorinated 2-chloroquinolines with ammonia

We have studied the interaction of polyfluorinated (in the benzene moiety) 2-chloroquinolines with liquid and aqueous ammonia as an approach to the synthesis of halogen-containing aminoquinolines. 5,7-Difluoro-, 5,6,8-trifluoro-, and 5,7,8-trifluoro-2-chloroquinolines mostly form products of substitution of the Cl atom, whereas 5,7-difluoro-2,6-dichloroquinoline, 5,6,7,8-tetrafluoro-, and 6,7-difluoro-2-chloroquinolines yield products of substitution of an F atom at various positions. The replacement of liquid ammonia with aqueous causes an increase in the proportion of the products of aminodechlorination relative to the products of aminodefluorination. For 2-chloro-6,8-difluoroquinoline this replacement leads to 2-amino-6,8-difluoroquinoline as the main product instead of the 8-amino-derivative. Activation energy values estimated by DFT calculations for the reactions in question agree with the reaction regioselectivity observed experimentally.

Reaction of pentafluoroacetanilide with zinc catalyzed by nickel complexes

The reaction of pentafluoroacetanilide hydrodefluorination under the action of zinc in the presence of catalytic amounts of complexes, generated in situ from nickel chloride and 2,2′-bipyridine or 1,10-phenanthroline, was studied. The influence of the sol

Synthesis of polyfluorinated 4-phenyl-3,4-dihydroquinolin-2-ones and quinolin-2-ones via superacidic activation of N-(polyfluorophenyl)cinnamamides

The cyclization reactions of a series of polyfluorocinnamanilides in triflic acid (CF3SO3H) yield 4-phenyl-3,4-dihydroquinolin-2-ones, which include a polyfluorinated benzene moiety as a part of the quinoline scaffold. These compounds undergo dehydrophenylation in the presence of AlCl3 to give the corresponding polyfluoroquinolin-2-ones which are converted into polyfluorinated 2-chloroquinolines on treatment with POCl3. A mechanism for the cyclization reaction presuming the intermediacy of a superelectrophilic O,C-diprotonated form of the starting material is suggested.