(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613721-49-5
Molecular Formula:C₁₇H₁₄FN₃O₂
Molecular Weight:311.315
Hs Code.:

Synonyms:(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Suppliers and Price of (R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Technology Process of (R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 3 articles about (R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1613721-90-6
C₁₁H₁₀BrN₃O₂

: 1993-03-9
o-fluorophenylboronic acid

: 1613721-49-5
(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: With 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 2h;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-88-2
(R)-2-(7-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-49-5
(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: Lawessons reagent / toluene / 3 h / Reflux

2: hydrazine hydrate / ethanol / 20 °C

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

With Lawessons reagent; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-89-3
(R)-2-(7-bromo-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-49-5
(R)-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 20 °C

2: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

With 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm5013006