(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613718-89-0
Molecular Formula:C₂₃H₂₅FN₄O₂
Molecular Weight:408.476
Hs Code.:

Synonyms:(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Chemical Property of (R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Technology Process of (R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 8 articles about (R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1613721-53-1
(R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride

: 1613718-89-0
(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: formaldehyd; (R)-7-(2-fluorophenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one hydrochloride; With acetic acid; In methanol; at 20 ℃; for 4h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-52-0
4-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]piperidine-1-carboxylic acid tert-butyl ester

: 1613718-89-0
(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

2.1: acetic acid / methanol / 4 h / 20 °C

2.2: 4 h / 20 °C

With hydrogenchloride; acetic acid; In methanol; ethyl acetate;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-50-8
(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 1613718-89-0
(R)-7-(2-fluorophenyl)-4-methyl-6-(1-methylpiperidin-4-yl)-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 50 °C / 2585.81 Torr

3.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

4.1: acetic acid / methanol / 4 h / 20 °C

4.2: 4 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1021/jm5013006