4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

Base Information

Chemical Name:4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile
CAS No.:178610-74-7
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

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Chemical Property of 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

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Technology Process of 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

There total 4 articles about 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 143-33-9,25596-52-5
sodium cyanide

: 178610-73-6
3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]propyl methanesulfonate

: 178610-74-7
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1021/jm010490l

Reference yield: 91.0%

: 178610-74-7
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

Guidance literature:

Reference yield:

: 4-[2-(furan-2-yl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

: 178610-74-7
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

3: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

4: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

5: 95 percent / dimethylformamide / 2 h / 80 °C

With sodium tetrahydroborate; hydrogen; sodium hydride; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; 1: Horner-Emmons reaction;
DOI:10.1021/jm010490l