4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

Base Information

Chemical Name:4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid
CAS No.:178610-75-8
Molecular Formula:C₂₀H₂₁NO₆
Molecular Weight:371.39
Hs Code.:

Synonyms:4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

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Chemical Property of 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

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Technology Process of 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

There total 4 articles about 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 178610-75-8
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

Guidance literature:

Reference yield: 94.0%

: 178610-74-7
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyronitrile

: 178610-75-8
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

Guidance literature:: With potassium hydroxide; In 2-methoxy-ethanol; for 2h; Heating;
DOI:10.1021/jm010490l

Reference yield:

: 4-[2-(furan-2-yl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

: 178610-75-8
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

3: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

4: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

5: 95 percent / dimethylformamide / 2 h / 80 °C

6: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Horner-Emmons reaction;
DOI:10.1021/jm010490l