methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

Base Information

Chemical Name:methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate
CAS No.:1417331-30-6
Molecular Formula:C₁₇H₁₉F₃N₂O₃Si
Molecular Weight:384.43
Hs Code.:

Synonyms:methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

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Chemical Property of methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

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Technology Process of methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

There total 11 articles about methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1417331-25-9
methyl 4-amino-6-chloro-5-fluoro-3-methoxypicolinate

: 1417332-36-5
(2,3-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

: 1417331-30-6
methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 115 ℃; for 0.333333h; microwave irradiation; sealed tube;

Reference yield:

: 1388157-65-0
isopropyl 4-amino-6-chloro-5-fluoropicolinate

: 1417331-30-6
methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate / 4 h / Reflux

2.1: iodine; periodic acid / methanol / 20 h / Reflux

3.1: caesium carbonate / 1,10-Phenanthroline; copper(l) iodide / methanol / 65 °C / Inert atmosphere

3.2: pH 2

4.1: hydrogenchloride / 4 h / 50 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; sealed tube

With titanium(IV) isopropylate; hydrogenchloride; iodine; sodium carbonate; caesium carbonate; periodic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,10-Phenanthroline; In methanol; water; acetonitrile;

Reference yield:

: 138871-01-9
1,2-difluoro-3-trimethylsilylbenzene

: 1417331-30-6
methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h / -75 - -70 °C

1.2: -70 - 25 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; sealed tube

With sec.-butyllithium; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; cyclohexane; water; acetonitrile;