methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

Base Information

Chemical Name:methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate
CAS No.:1417331-34-0
Molecular Formula:C₁₄H₁₀BrF₃N₂O₃
Molecular Weight:391.144
Hs Code.:

Synonyms:methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

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Chemical Property of methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

Chemical Property:

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Technology Process of methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

There total 12 articles about methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1417331-30-6
methyl 4-amino-6-(2,3-difluoro-4-(trimethylsilyl)phenyl)-5-fluoro-3-methoxypicolinate

: 1417331-34-0
methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: With bromine; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 138871-01-9
1,2-difluoro-3-trimethylsilylbenzene

: 1417331-34-0
methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h / -75 - -70 °C

1.2: -70 - 25 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; sealed tube

3.1: bromine / acetonitrile / 12 h / 20 °C

With bromine; sec.-butyllithium; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; cyclohexane; water; acetonitrile;

Reference yield:

: 496849-76-4
4,5,6-trichloro-pyridine-2-carboxylic acid methyl ester

: 1417331-34-0
methyl 4-amino-6-(4-bromo-2,3-difluorophenyl)-5-fluoro-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / 20 h / Dean-Stark apparatus; Reflux

1.2: 20 °C

2.1: cesium fluoride / 3.5 h / 100 - 110 °C / Dean-Stark apparatus; Inert atmosphere

3.1: ammonia / dimethyl sulfoxide / 2 h / 16 °C

4.1: hydrogenchloride / 1,4-dioxane / 20 - 100 °C

5.1: titanium(IV) isopropylate / 4 h / Reflux

6.1: iodine; periodic acid / methanol / 20 h / Reflux

7.1: caesium carbonate / 1,10-Phenanthroline; copper(l) iodide / methanol / 65 °C / Inert atmosphere

7.2: pH 2

8.1: hydrogenchloride / 4 h / 50 °C

9.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; sealed tube

10.1: bromine / acetonitrile / 12 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sulfuric acid; ammonia; bromine; iodine; sodium carbonate; caesium carbonate; periodic acid; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,10-Phenanthroline; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; acetonitrile;