2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

Base Information

Chemical Name:2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate
CAS No.:1281816-57-6
Molecular Formula:C₃₁H₂₈ClNO₃
Molecular Weight:498.021
Hs Code.:

Synonyms:2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

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Chemical Property of 2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

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Technology Process of 2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

There total 7 articles about 2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

: 103-82-2
phenylacetic acid

: 1281816-34-9
2-chloro-1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

: 1281816-57-6
2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

Guidance literature:: phenylacetic acid; With triethylamine; In acetone; for 0.25h;

2-chloro-1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone; In acetone; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

: 1003-85-6
5.5-dimethyl-1,3,2-dioxathiane-2-oxide

: 1281816-57-6
2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 36 h / 100 °C

2.1: pyridine; thionyl chloride / 0 °C

3.1: diethyl ether / 2 h / Reflux

3.2: 3 h / Reflux

4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

5.1: boron trifluoride diethyl etherate / diethyl ether / 20 °C / Inert atmosphere

6.1: triethylamine / acetone / 0.25 h

6.2: 24 h / 20 °C

With pyridine; thionyl chloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; triethylamine; In diethyl ether; ethanol; dimethyl sulfoxide; acetone;
DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 1281816-57-6
2-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)-2-oxoethyl 2-phenylacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / dichloromethane / 5 - 10 °C

2.1: dimethyl sulfoxide / 36 h / 100 °C

3.1: pyridine; thionyl chloride / 0 °C

4.1: diethyl ether / 2 h / Reflux

4.2: 3 h / Reflux

5.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

6.1: boron trifluoride diethyl etherate / diethyl ether / 20 °C / Inert atmosphere

7.1: triethylamine / acetone / 0.25 h

7.2: 24 h / 20 °C

With pyridine; thionyl chloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; triethylamine; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/j.ejmech.2011.01.002