Technology Process of 17α-hydroxypropargyl-β-estradiolyl 2-phenylquinoline-4-carboxylate
There total 4 articles about 17α-hydroxypropargyl-β-estradiolyl 2-phenylquinoline-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; acetic acid;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
DOI:10.1039/b708947c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 0 - 25 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 17 h / 25 °C
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
4.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 0 - 20 °C
With
2,6-dimethylpyridine; dmap; tetrabutyl ammonium fluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/c1ob05629h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
1.2: 17 h / 25 °C
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 0 - 20 °C
With
dmap; tetrabutyl ammonium fluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/c1ob05629h
