<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

Base Information

Chemical Name:<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole
CAS No.:79681-07-5
Molecular Formula:C₂₅H₂₉NO₄S
Molecular Weight:439.576
Hs Code.:

Synonyms:<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

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Chemical Property of <3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

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Technology Process of <3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

There total 6 articles about <3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 79681-06-4
<3S-(E)>-4-(4-hydroxy-3-methyl-1-butenyl)-1-<(4-methylphenyl)sulfonyl>-1H-indole

: 79681-07-5
<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1021/jo00338a049

Reference yield:

: 79681-04-2
1-[(4-methyl-phenyl)-sulfonyl]-1H-indol-4-carboxaldehyde

: 79681-07-5
<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

2: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂

With pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1021/jo00338a049

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 79681-07-5
<3-S-(E)>-4-<3-methyl-4-<(tetrahydro-2H-pyran-2yl)oxy>-1-butenyl>-1-<(4-methylphenyl)sulfonyl>-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1: 92.4 percent / K₂CO₃ / butan-2-one / 24 h / Heating

2: 85.3 percent / lithium aluminium hydride / tetrahydrofuran / 0.75 h / 0 - 5 °C

3: 96.6 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 2.5 h / Ambient temperature

4: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C - RT, 3 h; 2.) -78 deg C - RT, 2h

5: pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; sodium acetate; potassium carbonate; pyridinium chlorochromate; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; butanone;
DOI:10.1016/0040-4020(84)80018-6