(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

Base Information

Chemical Name:(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate
CAS No.:1334324-53-6
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:

Synonyms:(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

Chemical Property:

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Technology Process of (R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

There total 2 articles about (R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1334324-75-2
C₁₅H₁₉NO₅

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1334324-53-6
(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 45 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol202276h

Reference yield:

: 93204-36-5
(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate

: 1334324-53-6
(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 10 h / 60 °C / Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Hoveyda-Grubbs catalyst second generation; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol202276h

Reference yield:

: 1334324-53-6
(R,E)-methyl 2-(((benzyloxy)carbonyl)amino)-3-((4-oxopent-2-en-1-yl)oxy)propanoate

: 1334324-19-4
(3R,5R)-4-benzyl 3-methyl 5-(2-oxopropyl)morpholine-3,4-dicarboxylate

: (3R,5S)-4-benzyl 3-methyl 5-(2-oxopropyl)morpholine-3,4-dicarboxylate

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at -20 ℃; for 5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202276h