(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

Base Information

Chemical Name:(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene
CAS No.:472954-88-4
Molecular Formula:C₄₃H₆₃NO₂Si
Molecular Weight:654.064
Hs Code.:

Synonyms:(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

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Technology Process of (2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

There total 4 articles about (2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124-25-4,511542-15-7
myristylaldehyde

: 472954-87-3
[4-(tert-butyldimethylsilanyloxy)-3-tritylamino-2-oxo-butyl]phosphonic acid dimethyl ester

: 472954-88-4
(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1016/S0957-4166(02)00118-0

Reference yield:

: 98642-61-6
(2S)-2-amino-3-(tert-butyldimethylsilanyloxy)propionic acid methyl ester

: 472954-88-4
(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.53 g / triethylamine / CH₂Cl₂ / 2 h / Heating

2: 12 g / n-butyllithium / hexane; tetrahydrofuran / -78 - -20 °C

3: 95 percent / DBU; LiCl / tetrahydrofuran / 5 h / 20 °C

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0957-4166(02)00118-0

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 472954-88-4
(2S,4E)-2-[N-(trityl)amino]-1-O-tert-butyldimethylsilyl-3-oxo-4-octadecene

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 48 h / 20 °C

2: 1.53 g / triethylamine / CH₂Cl₂ / 2 h / Heating

3: 12 g / n-butyllithium / hexane; tetrahydrofuran / -78 - -20 °C

4: 95 percent / DBU; LiCl / tetrahydrofuran / 5 h / 20 °C

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; 4: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0957-4166(02)00118-0