(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

Base Information

Chemical Name:(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol
CAS No.:1350766-67-4
Molecular Formula:C₄₂H₄₈O₃Si
Molecular Weight:628.927
Hs Code.:

Synonyms:(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

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Chemical Property of (3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

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Technology Process of (3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

There total 4 articles about (3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1350766-65-2
(R)-2-[(S)-2-(tert-butyldiphenylsiloxy)-4-phenylbutyl]oxirane

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1350766-67-4
(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

Guidance literature:: 4-(benzyloxy)benzyl bromide; With copper(l) iodide; magnesium; In tetrahydrofuran; at 25 ℃; for 0.5h;

(R)-2-[(S)-2-(tert-butyldiphenylsiloxy)-4-phenylbutyl]oxirane; In tetrahydrofuran; at -20 - 25 ℃; for 1h;
DOI:10.1055/s-0030-1260183

Reference yield:

: 1350766-63-0
(S)-4-(tert-butyldiphenylsiloxy)-6-phenylhex-1-ene

: 1350766-67-4
(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 25 °C

2.1: (R,R)-Jacobsen catalyst; water; acetic acid / toluene / 14.08 h / 0 - 25 °C

3.1: copper(l) iodide; magnesium / tetrahydrofuran / 0.5 h / 25 °C

3.2: 1 h / -20 - 25 °C

With copper(l) iodide; (R,R)-Jacobsen catalyst; water; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1055/s-0030-1260183

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1350766-67-4
(3S,5S)-1-[4-(benzyloxy)phenyl]-5-(tert-butyldiphenylsiloxy)-7-phenylheptan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: C₄₆H₃₈O₇Ti₂ / dichloromethane / 24 h / -15 - 0 °C

2.1: 1H-imidazole / dichloromethane / 4 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 25 °C

4.1: (R,R)-Jacobsen catalyst; water; acetic acid / toluene / 14.08 h / 0 - 25 °C

5.1: copper(l) iodide; magnesium / tetrahydrofuran / 0.5 h / 25 °C

5.2: 1 h / -20 - 25 °C

With 1H-imidazole; copper(l) iodide; (R,R)-Jacobsen catalyst; C₄₆H₃₈O₇Ti₂; water; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1055/s-0030-1260183