2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

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Chemical Name:2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester
CAS No.:921771-34-8
Molecular Formula:C₄₄H₆₂N₄O₁₃
Molecular Weight:854.995
Hs Code.:

2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-<i>tert</i>-butoxycarbonyl-butyrylamino)-6-<i>tert</i>-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

Synonyms:2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

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Chemical Property of 2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

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Technology Process of 2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

There total 8 articles about 2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 921771-33-7
2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

: 921771-34-8
2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1021/jm060385h

Reference yield:

: 917877-01-1
R-3-(2,2-dimethyl[1,3]dioxolan-4-yl)-acrylic acid ethyl ester

: 921771-34-8
2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / 48 h / -50 °C

2: 86 percent / H₂ / Pd/C / ethanol / 12 h / atmospheric pressure

3: 85 percent / CH₂Cl₂ / 12 h / 20 °C

4: 92 percent / H₂ / Pd/C / methanol / 4 h / atmospheric pressure

5: 81 percent / CH₂Cl₂ / 12 h / 20 °C

6: 70 percent / montmorillonite K₁₀ / ethanol; H₂O / 3 h / 75 °C

7: 72 percent / DMAP; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; pyridine / 72 h / 20 °C

8: 80 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 20 °C

With pyridine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Montmorillonite K₁₀; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm060385h

Reference yield:

: 165133-39-1
3-benzylamino-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid ethyl ester

: 921771-34-8
2,6-dimethyl-benzoic acid 3-[2-(2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-4-ethoxycarbonyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / H₂ / Pd/C / ethanol / 12 h / atmospheric pressure

2: 85 percent / CH₂Cl₂ / 12 h / 20 °C

3: 92 percent / H₂ / Pd/C / methanol / 4 h / atmospheric pressure

4: 81 percent / CH₂Cl₂ / 12 h / 20 °C

5: 70 percent / montmorillonite K₁₀ / ethanol; H₂O / 3 h / 75 °C

6: 72 percent / DMAP; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; pyridine / 72 h / 20 °C

7: 80 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 20 °C

With pyridine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Montmorillonite K₁₀; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm060385h