7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:120685-93-0
Molecular Formula:C₁₇H₁₇ClINO
Molecular Weight:413.686
Hs Code.:

Synonyms:7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 6 articles about 7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 133956-16-8
7-chloro-8-methoxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 120685-93-0
7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With boron tribromide; In dichloromethane; 1) dry ice/2-propanol bath --> room temperature, 29 room temperature, 2 h;
DOI:10.1021/jm00127a005

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 120685-93-0
7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / acetonitrile / Heating

2: 84 percent / conc. H₂SO₄ / 1) 8 deg C, 30 min, 2) room temperature, 90 min

3: 80 percent / formic acid / 4 h / 90 - 100 °C

5: 33 percent / BBr₃ / CH₂Cl₂ / 1) dry ice/2-propanol bath --> room temperature, 29 room temperature, 2 h

With sulfuric acid; boron tribromide; In formic acid; dichloromethane; acetonitrile;
DOI:10.1021/jm00127a005

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 120685-93-0
7-chloro-8-hydroxy-1-(4'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 47.4 percent / Cl₂, HCl / H₂O; acetic acid / 0.17 h

2: 40 percent / acetonitrile / Heating

3: 84 percent / conc. H₂SO₄ / 1) 8 deg C, 30 min, 2) room temperature, 90 min

4: 80 percent / formic acid / 4 h / 90 - 100 °C

6: 33 percent / BBr₃ / CH₂Cl₂ / 1) dry ice/2-propanol bath --> room temperature, 29 room temperature, 2 h

With hydrogenchloride; sulfuric acid; chlorine; boron tribromide; In formic acid; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1021/jm00127a005