(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

Base Information

Chemical Name:(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate
CAS No.:1604009-09-7
Molecular Formula:C₁₇H₂₁Cl₂NO₃
Molecular Weight:358.265
Hs Code.:

Synonyms:(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

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Chemical Property of (R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

There total 5 articles about (R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1604009-09-7
(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: With hydrogen; C₃₂H₁₂BF₂₄^(1-)*C₄₃H₅₄IrNOP⁽¹⁺⁾; In 1,2-dichloro-ethane; at 20 ℃; for 12h; enantioselective reaction; Autoclave;

Reference yield:

: 1604008-39-0
(E)-tert-butyl 3-(3,4-dichlorobenzylidene)-2-oxopiperidine-1-carboxylate

: 1604009-09-7
(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: With C₃₆H₄₄IrNOP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; In dichloromethane; at 20 ℃; under 760.051 Torr; enantioselective reaction; Inert atmosphere; Glovebox; Autoclave;
DOI:10.1002/anie.201309521

Reference yield:

: 675-20-7
piperidin-2-one

: 1604009-09-7
(R)-(+)-tert-butyl 3-(3,4-dichlorobenzyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 1 h / 5 - 20 °C

2: potassium tert-butylate / tetrahydrofuran / 1 h / 55 °C / Cooling with ice

3: dmap; triethylamine / dichloromethane / 5 h / 20 °C

4: C₃₆H₄₄IrNOP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere; Glovebox; Autoclave

With dmap; C₃₆H₄₄IrNOP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.201309521