(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

Base Information

Chemical Name:(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide
CAS No.:1253943-69-9
Molecular Formula:C₂₅H₁₉F₃N₂O₂
Molecular Weight:436.433
Hs Code.:

Synonyms:(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

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Chemical Property of (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

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Technology Process of (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

There total 5 articles about (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 96794-40-0
PhCHCHBCat

: 1253943-54-2
N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

: 1253943-69-9
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

Guidance literature:: PhCHCHBCat; N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 0.25h; Microwave irradiation; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In 1,4-dioxane; water; benzene; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201000158

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1253943-69-9
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 3 h / Inert atmosphere

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium / tetrahydrofuran; hexane / 0 - 25 °C / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

3.1: pyridine / 25 °C

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; acetone; 4.1: Suzuki cross coupling;
DOI:10.1002/cmdc.201000158

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1253943-69-9
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-phenyl ethen-1-yl benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium / tetrahydrofuran; hexane / 0 - 25 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: pyridine / 25 °C

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; In tetrahydrofuran; 1,4-dioxane; hexane; 3.1: Suzuki cross coupling;
DOI:10.1002/cmdc.201000158