N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

Base Information

Chemical Name:N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate
CAS No.:1253943-54-2
Molecular Formula:C₁₈H₁₂F₆N₂O₅S
Molecular Weight:482.36
Hs Code.:

Synonyms:N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

There total 4 articles about N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1253943-53-1
N-(4-cyano-3-trifluoromethylphenyl)-6-ethoxy-2-hydroxybenzamide

: 1253943-54-2
N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 25 ℃;
DOI:10.1002/cmdc.201000158

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1253943-54-2
N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 3 h / Inert atmosphere

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium / tetrahydrofuran; hexane / 0 - 25 °C / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

3.1: pyridine / 25 °C

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetone;
DOI:10.1002/cmdc.201000158

Reference yield:

: 1253943-52-0
5-ethoxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one

: 1253943-54-2
N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium / tetrahydrofuran; hexane / 0 - 25 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: pyridine / 25 °C

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1002/cmdc.201000158