ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

Base Information

Chemical Name:ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate
CAS No.:150610-94-9
Molecular Formula:C₃₀H₃₄N₂O₅S
Molecular Weight:534.676
Hs Code.:

Synonyms:ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

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Chemical Property of ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

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Technology Process of ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

There total 8 articles about ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propenoate

: 150610-94-9
ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr;
DOI:10.1016/j.bmc.2004.02.032

Reference yield:

: 70080-54-5
4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester

: 150610-94-9
ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol; tetrahydrofuran / 3 h / 20 °C

3: 1.92 g / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Mitsunobu reaction / 2: Wittig reaction;
DOI:10.1016/j.bmc.2004.02.032

Reference yield:

: 105191-15-9
2-(hydroxymethyl)benzo[b]thiophene-5-carbonitrile

: 150610-94-9
ethyl 2-(4-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}phenyl)-3-(5-cyano-1-benzothien-2-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂; pyridine / diethyl ether / 2 h / 20 °C

2: 6.3 g / xylene / 10 h / Heating

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol; tetrahydrofuran / 3 h / 20 °C

4: 1.92 g / H₂ / Pd/C / ethanol / 20 °C / 760 Torr

With pyridine; thionyl chloride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; xylene; 3: Wittig reaction;
DOI:10.1016/j.bmc.2004.02.032