Tert-butyl 4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 4-hydroxypiperidine-1-carboxylate
• CAS No.: 109384-19-2
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• Hs Code.: 29339900
• European Community (EC) Number: 600-916-6
• DSSTox Substance ID: DTXSID40349203
• Nikkaji Number: J1.097.794K
• Wikipedia: 1-boc-4-piperidinol
• Wikidata: Q72449624
• Mol file: 109384-19-2.mol

Synonyms:109384-19-2;n-boc-4-hydroxypiperidine;1-Boc-4-hydroxypiperidine;tert-butyl 4-hydroxypiperidine-1-carboxylate;1-Boc-4-piperidinol;N-Boc-4-piperidinol;1-Boc-4-Hydroxy-piperidine;MFCD01075174;1-tert-Butoxycarbonyl-4-hydroxypiperidine;1-(tert-Butoxycarbonyl)-4-hydroxypiperidine;4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-piperidinecarboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester;N-tert-butoxycarbonyl-4-hydroxypiperidine;4-Hydroxypiperidine-1-carboxylic acid tert-butyl ester;n-boc-4-hydroxylpiperidine;n-boc-4-hydroxy piperidine;Boc-(4-hydroxy)piperidine;N-Boc-4-hydroxy-piperidine;n-(tert-butoxycarbonyl)-4-piperidinol;N-Boc 4-piperidinol;1-Bocpiperidin-4-ol;1-(tert-butyloxycarbonyl)-4-piperidinol;1-Boc-piperidin-4-ol;1-Boc-piperidine-4-ol;N-Boc4-hydroxypiperidine;4-hydroxy-boc-piperidine;Maybridge3_000273;tert-Butyl 4-hydroxy-1-piperidinecarboxylate;4-hydroxy-1-Bocpiperidine;N-BOC 4-hydroxypiperidine;4-hydroxy-n-boc piperidine;4-hydroxy-n-boc-piperidine;1-boc-4-hydroxy piperidine;4-hydroxy-1-boc-piperidine;boc-(4-hydroxy)-piperidine;1-N-Boc-4-hydroxypiperdine;SCHEMBL47319;N-(TERT-BUTOXYCARBONYL)-4-HYDROXYPIPERIDINE;1-N-Boc-4-hydroxy-piperidine;F3146-0160;tert-butoxycarbonylpiperidin-4-ol;1-t-Butoxycarbonyl-4-piperidinol;DTXSID40349203;1-t-butoxycarbonylpiperidine-4-ol;1-Boc-4-hydroxypiperidine, 97%;HMS1431M09;1-t-butyloxycarbonylpiperidin-4-ol;1-tert-butoxycarbonylpiperidin-4-ol;BCP23228;CS-M0052;N-(t-butoxycarbonyl)-4-piperidinol;N-tert-butoxycarbonylpiperidin-4-ol;1-tert-butoxycarbonylpiperidine-4-ol;AB1263;BBL029147;STL065851;1(tert-Butoxycarbonyl)piperidin-4-ol;1-(t-butyloxycarbonyl)-4-piperidinol;N-tert-butyloxycarbonyl-4-piperidinol;1-t-butoxycarbonyl-4-hydroxypiperidine;4-hydroxy-1-t-butoxycarbonylpiperidine;AKOS000499733;n-(tert-butoxycarbonyl)-piperidin4-ol;N-t-butoxycarbonyl-4-hydroxypiperidine;tert-butoxycarbonyl-4-hydroxypiperidine;AC-2551;CCG-236453;PB29134;PS-5411;1-(tert-Butoxycarbonyl)piperidine-4-ol;1-tertbutoxycarbonyl-4-hydroxypiperidine;IDI1_011660;N-(t-butoxycarbonyl)4-hydroxypiperidine;N-(tert-Butoxycarbonyl)-piperidin-4-ol;N-(tert-butyloxycarbonyl)-4-piperidinol;4-hydroxy-N-(t-butoxycarbonyl)piperidine;N-tert-butoxycarbonyl 4-hydroxypiperidine;1-tert-butoxycarbonyl4-hydroxy-piperidine;4-hydroxy-1-tert-butoxycarbonylpiperidine;N-(tert-butyloxy-carbonyl)-4-piperidinol;SY001987;t-butyl 4-hydroxy-1-piperidinecarboxylate;t-butyl 4-hydroxypiperidine-1-carboxylate;t-butyl-4-hydroxy-1-piperidinecarboxylate;tert-butyl 4-hydroxy-piperidinecarboxylate;tert-butyl 4-hydroxypiperidine carboxylate;1-N-t-butyloxycarbonyl-4-hydroxypiperidine;1-Tert-butoxycarbonyl-4-hydroxy-piperidine;N-tert-Butoxycarbonyl-4- Hydroxypiperidine;N-tert-butoxycarbonyl-4-hydroxy-piperidine;1-tert-butyloxycarbonyl-4-hydroxypiperidine;t-butyl-4-hydroxy-1-piperidine carboxylate;tert-butyl 4-hydroxy-1-piperdinecarboxylate;tert-butyl 4-hydroxypiperidin-1-carboxylate;1-tert-butyloxycarbonyl-4-hydroxy-piperidine;AM20080047;B2671;BB 0254792;FT-0642678;tert-butyl 4 hydroxypiperidine-1-carboxylate;tert-butyl-4-hydroxy-1-piperidinecarboxylate;tert-butyl-4-hydroxypiperidine-1-carboxylate;tert.butyl 4-hydroxypiperidine-1-carboxylate;tert.butyl-4-hydroxypiperidine-1-carboxylate;1-(tert-butyloxycarbonyl)-4-hydroxypiperidine;EN300-27439;tert-BUTOXYCARBONYL-4-HYDROXY-PIPERIDINE;tert-butyl -4-hydroxypiperidine-1-carboxylate;tert-butyl 4-(hydroxy)piperidin-1-carboxylate;tert-butyl 4-hydroxy-1--piperidinecarboxylate;tert-butyl 4-hydroxy-1-piperidine carboxylate;tert-butyl 4-hydroxy-1-piperidine-carboxylate;tert-butyl 4-hydroxy-piperidine-1-carboxylate;tert-butyl 4-hydroxypiperidin-1-ylcarboxylate;tert-butyl-4-hydroxy-1-piperidine carboxylate;tert-Butyl-4-hydroxy-1-piperidine-carboxylate;tert. butyl 4-hydroxypiperidine-1-carboxylate;VU0510739-1;1,1-dimethylethyl 4-hydroxypiperidinecarboxylate;tert-butyl (4-hydroxy)-piperidine-1-carboxylate;1,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate;4-hydroxypiperidine-1-carboxylic acid t-butyl ester;Q-101209;2-methylpropan-2-yl 4-hydroxypiperidine-1-carboxylate;4-hydroxy-1-piperidinecarboxylic acid tert-butyl ester;4-hydroxy-piperidin-1-carboxylic acid tert-butyl ester;4-hydroxy-piperidine-1-carboxylic acid t-butyl ester;4-hydroxy-piperidine-1-carboxylic acid-tert-butylester;4-Hydroxy-piperdine-1-carboxylic acid tert-butyl ester;4-Hydroxy-piperidine-1-carboxylic acid tert-butyl-ester;4-Hydroxy-piperidine-1-carboxylic-acid tert-butyl ester;4-hydroxypiperidine-1-car-boxylic-acid-tert-butyl ester;tert-Butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate;Z111782472;1,1-DIMETHYLETHYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE

Chemical Property of Tert-butyl 4-hydroxypiperidine-1-carboxylate

Chemical Property:

• Appearance/Colour: white or off-white crystalline powder
• Vapor Pressure: 0.000198mmHg at 25°C
• Melting Point: 60-65 ºC
• Refractive Index: 1.495
• Boiling Point: 292.3 ºC at 760 mmHg
• PKA: 14.80±0.20(Predicted)
• Flash Point: 130.6 ºC
• PSA: 49.77000
• Density: 1.107 g/cm³
• LogP: 1.31610
• Storage Temp.: Store at -15°C
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 201.13649347
• Heavy Atom Count: 14
• Complexity: 202

Purity/Quality:

98%, ^*data from raw suppliers

1-Boc-4-piperidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)O
• Uses: N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds. Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.

Technology Process of Tert-butyl 4-hydroxypiperidine-1-carboxylate

There total 30 articles about Tert-butyl 4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-HYDROXYPIPERIDINE (5382-16-1) + di-tert-butyl dicarbonate (24424-99-5) → t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2)

Guidance literature:

With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃;

Reference yield: 100.0%

4-HYDROXYPIPERIDINE (5382-16-1) + tert-butyldicarbonate (34619-03-9) → t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; for 15h;

Reference yield: 100.0%

4-HYDROXYPIPERIDINE (5382-16-1) → t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2)

Guidance literature:

With tert-butyldicarbonate; triethylamine; In dichloromethane; at 0 ℃; for 21h;

upstream raw materials:

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate

N-tert-butyloxycarbonylpiperidin-4-one

t-butyl piperidinecarboxylate

Downstream raw materials:

4-(3-Ethoxycarbonyl-benzyloxy)-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(4-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

Refernces

• 1、 Bashetti, Nagaraju,Shanmukha Kumar,Seelam, Naresh Varma,Prasanna,Mintz, Akiva,Damuka, Naresh,Devanathan, Sriram,Solingapuram Sai, Kiran Kumar. "One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists". . . Retrieved 2019.
• 2、 Hoelemann, Alexandra,Reissig, Hans-Ulrich. "Regioselective samarium diiodide induced couplings of carbonyl compounds with 1,3-diphenylallene and alkoxyallenes: A new route to 4-hydroxy-1-enol ethers". . p. 5493 - 5506. Retrieved 2004.
• 3、 Darandale, Sunil N.,Mulla, Nayeem A.,Pansare, Dattatraya N.,Sangshetti, Jaiprakash N.,Shinde, Devanand B.. "A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity". . p. 527 - 532. Retrieved 2013.
• 4、 Elsohly, Adel M.,Wespe, Daniel A.,Poore, Tyler J.,Snyder, Scott A.. "An Efficient approach to the securinega alkaloids empowered by cooperative n-heterocyclic carbene/lewis acid catalysis". . p. 5789 - 5794. Retrieved 2013.
• 5、 Li, Jiaoyan,Ma, Yingmiao,Wang, Zheng,Liu, Qingbin,Solan, Gregory A.,Ma, Yanping,Sun, Wen-Hua. "An air and moisture tolerant iminotrihydroquinoline-ruthenium(ii) catalyst for the transfer hydrogenation of ketones". . p. 8738 - 8745. Retrieved 2018.
• 6、 Zhang, Ming-Rong,Furutsuka, Kenji,Maeda, Jun,Kikuchi, Tatsuya,Kida, Takayo,Okauchi, Takashi,Irie, Toshiaki,Suzuki, Kazutoshi. "N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo.". . p. 2519 - 2527. Retrieved 2003.
• 7、 Bessières, Maxime,Plebanek, El?bieta,Chatterjee, Payel,Shrivastava-Ranjan, Punya,Flint, Mike,Spiropoulou, Christina F.,Warszycki, Dawid,Bojarski, Andrzej J.,Roy, Vincent,Agrofoglio, Luigi A.. "Design, synthesis and biological evaluation of 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles as inhibitors of ebola virus infection". . . Retrieved 2021/02/06.