3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide
CAS No.:1282520-01-7
Molecular Formula:C₂₂H₂₁FN₂O₂S
Molecular Weight:396.485
Hs Code.:

Synonyms:3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

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Chemical Property of 3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Chemical Property:

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Technology Process of 3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

There total 7 articles about 3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1282520-83-5
3-(triphenylphosphonium bromide-methyl)-5-isobutoxy-N-(thiazol-2-yl)benzamide

: 446-52-6
2-Fluorobenzaldehyde

: 1282520-01-7
3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: With potassium hydroxide; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1185753-91-6
dimethyl 5-(isobutyloxy)isophthalate

: 1282520-01-7
3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; methanol / tetrahydrofuran / 10 h / 100 °C

2: dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: lithium borohydride; ethanol / tetrahydrofuran / 48 h / 0 - 20 °C

4: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5: benzene / 6 h / 100 °C

6: potassium hydroxide / 18-crown-6 ether / dichloromethane / 12 h / 20 °C

With methanol; lithium borohydride; ethanol; tribromo phosphate; dicyclohexyl-carbodiimide; potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; benzene;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-01-7
3-[trans-2-(2-fluorophenyl)vinyl]-5-isobutoxy-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 40 °C

2: potassium hydroxide; methanol / tetrahydrofuran / 10 h / 100 °C

3: dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

4: lithium borohydride; ethanol / tetrahydrofuran / 48 h / 0 - 20 °C

5: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

6: benzene / 6 h / 100 °C

7: potassium hydroxide / 18-crown-6 ether / dichloromethane / 12 h / 20 °C

With methanol; lithium borohydride; ethanol; tribromide phosphate; potassium carbonate; dicyclohexyl-carbodiimide; potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;