(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

Base Information

Chemical Name:(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate
CAS No.:1407510-10-4
Molecular Formula:C₂₀H₁₉FN₂O₃
Molecular Weight:354.381
Hs Code.:

Synonyms:(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

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Chemical Property of (R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

Chemical Property:

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Technology Process of (R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

There total 3 articles about (R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 4299-70-1,7303-49-3,22032-65-1
D-Tryptophan methyl ester

: 459-04-1
4-Fluorophenylacetyl chloride

: 1407510-10-4
(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

Guidance literature:: With triethylamine; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.2174/157340612802084342

Reference yield:

: 153-94-6,27732-43-0,80206-30-0,27813-82-7
D-tryptophan

: 1407510-10-4
(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: 5 h / 0 °C / Reflux

3: triethylamine; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.2174/157340612802084342

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 1407510-10-4
(R)-methyl 2-(2-(4-fluorophenyl)acetamido)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.2174/157340612802084342