4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Base Information

Chemical Name:4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester
CAS No.:345898-19-3
Molecular Formula:C₂₆H₂₉N₃O₈
Molecular Weight:511.532
Hs Code.:

4,N<sup>7</sup>-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Synonyms:4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

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Chemical Property of 4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Chemical Property:

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Technology Process of 4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

There total 6 articles about 4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 345898-18-2
4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid

: 345898-19-3
4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1246/bcsj.77.331

Reference yield:

: 10494-79-8
methyl N-(3-hydroxypropyl)-β-alaninate

: 345898-19-3
4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 11.3 g / Et₃N / tetrahydrofuran / 20 °C

2.1: Et₃N / toluene / 2 h / 0 °C

3.1: 7.94 g / NaN₃; (n-Bu)4NBr / toluene; H₂O / 80 °C

4.1: PPh₃ / tetrahydrofuran; H₂O / 30 h / 20 °C

4.2: 71.8 percent / Na₂CO₃ / diethyl ether; tetrahydrofuran; H₂O / 20 °C

5.1: NaOH / H₂O; methanol / 1.5 h / 60 °C

6.1: EDC*HCl / dimethylformamide / 20 °C

With sodium hydroxide; sodium azide; tetrabutylammomium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.77.331

Reference yield:

: 177906-29-5
methyl 7-azido-4-benzyloxycarbonyl-4-azaheptanoate

: 345898-19-3
4,N⁷-bis(benzyloxycarbonyl)-7-amino-4-azaheptanoic acid succinimidyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃ / tetrahydrofuran; H₂O / 30 h / 20 °C

1.2: 71.8 percent / Na₂CO₃ / diethyl ether; tetrahydrofuran; H₂O / 20 °C

2.1: NaOH / H₂O; methanol / 1.5 h / 60 °C

3.1: EDC*HCl / dimethylformamide / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331