rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide

Base Information

• Chemical Name: rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide
• CAS No.: 1188422-69-6
• Molecular Formula: C₃₈H₅₀N₆O₆S
• Molecular Weight: 718.918

Synonyms:rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide

Chemical Property of rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide

There total 5 articles about rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

rac-(3aR,14bR)-10-cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a-dimethyl-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide + N-methyl-L-proline hydrochloride (89614-97-1) → rac-(3aR,14bR)-10-cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide (1188422-69-6)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester (902148-54-3) → rac-(3aR,14bR)-10-cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide (1188422-69-6)

Guidance literature:

Multi-step reaction with 5 steps

1: trifluoroacetic acid / tetrahydrofuran / 32 h / Inert atmosphere

2: water; sodium hydroxide / tetrahydrofuran; methanol / 72 h

3: triethylamine; HATU / N,N-dimethyl-formamide

4: hydrogen / palladium on activated charcoal / methanol; ethanol / 16 h / 2585.81 Torr / Inert atmosphere

5: triethylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With water; hydrogen; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

rac-(3aR,14bR)-2-benzyl-10-cyclohexyl-7-((dimethylsulfamoyl)carbamoyl)-13-methoxy-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a(4H)-carboxylic acid → rac-(3aR,14bR)-10-cyclohexyl-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide (1188422-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide

2: hydrogen / palladium on activated charcoal / methanol; ethanol / 16 h / 2585.81 Torr / Inert atmosphere

3: triethylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogen; triethylamine; HATU; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

N-methyl-L-proline hydrochloride

13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1188422-69-6 rac-(3aR,14bR)-10-cyclohexyl-N₇-(dimethylsulfamoyl)-13-methoxy-N₃a,N₃a-dimethyl-2-(1-methyl-L-prolyl)-1,2,3,14b-tetrahydroindolo[2,1-a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send