2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Base Information

• Chemical Name: 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate
• CAS No.: 1415829-74-1
• Molecular Formula: C₂₈H₂₅N₅O₅S
• Molecular Weight: 543.603
• Mol file: 1415829-74-1.mol

Synonyms:2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Chemical Property of 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

There total 6 articles about 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-(allyloxy)ethyl 4-sulfamoylphenylcarbamate (1415830-63-5) + 8-(methylsulfonyl)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine (1415830-54-4) → 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate (1415829-74-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1002/psc.3353

Reference yield:

8-(methylthio)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine (1415830-52-2) → 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate (1415829-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

2.2: 16 h / 100 °C / Inert atmosphere

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-Bromo-2'-acetonaphthone (613-54-7) → 2-(allyloxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate (1415829-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; tert-butyl alcohol / 40 h / Reflux

2.1: dimethyl sulfoxide / 16 h / 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

4.2: 16 h / 100 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

ethylene glycol monoallyl ether

4-(aminosulfonyl)-benzoic acid

2-Bromo-2'-acetonaphthone

8-(methylthio)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine