6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

Base Information

Chemical Name:6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one
CAS No.:1371535-16-8
Molecular Formula:C₂₀H₂₅FN₂O₂S
Molecular Weight:376.495
Hs Code.:

Synonyms:6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

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Chemical Property of 6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

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Technology Process of 6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

There total 4 articles about 6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1428569-08-7
C₂₀H₂₃FN₂O₂S

: 1371535-16-8
6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; Cooling with ice;
DOI:10.2174/157018013804999726

Reference yield:

: 1268381-90-3
C₁₂H₁₈N₂OS

: 1371535-16-8
6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / Cooling with ice

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.2174/157018013804999726

Reference yield:

: 5292-21-7
Cyclohexylacetic acid

: 1371535-16-8
6-(cyclohexylmethyl)-2-((2-(4-fluorophenyl)-2-hydroxyethyl)thio)-5-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 20 °C

1.2: 20 °C / Reflux

2.1: sodium ethanolate / ethanol / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran; methanol / Cooling with ice

With sodium tetrahydroborate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.2174/157018013804999726