5292-21-7

Basic information

• Product Name: Cyclohexylacetic acid
• Synonyms: NCI 204816;Cyclohexylacetic acid ,98%;2-Cyclohexylethanoic acid, (Carboxymethyl)cyclohexane;Cyclohexaneacetic acid >=99%;Cyclohexylacetic Acid , 98.0%(GC&T;Cyclohexylethanoic acid;FEMA 3531;FEMA 2347
• CAS NO: 5292-21-7
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.2
• EINECS: 202-711-3
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Acids and Derivatives
• Mol File: 5292-21-7.mol
• Article Data: 46

Chemical Properties

• Melting Point: 29-31 °C(lit.)
• Boiling Point: 242-244 °C(lit.)
• Flash Point: >230 °F
• Appearance: White to pale yellow/Low Melting Solid
• Density: 1.007 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00961mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:4.51 (25°C)
• BRN: 2041326
• CAS DataBase Reference: Cyclohexylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexylacetic acid(5292-21-7)
• EPA Substance Registry System: Cyclohexylacetic acid(5292-21-7)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: GU8370000
• TSCA: Yes
• Hazardous Substances Data: 5292-21-7(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 5292-21-7 differently. You can refer to the following data:
1. Cyclohexane acetic acid has a sharp acetic odor.
2. White to pale yellow low melting solid

Definition

ChEBI: A monocarboxylic acid consisting of cyclohexane carrying a carboxymethyl substituent.

Aroma threshold values

Detection: 19 ppm

Taste threshold values

Taste characteristics at 100 ppm: honey, caramellic, maple and cocoa.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 3595, 1993 DOI: 10.1021/jo00065a028

General Description

Cyclohexaneacetic acid is used as a flavoring agent in the food industry.

InChI:InChI=1/C8H14O2/c9-8(10)6-7-4-2-1-3-5-7/h7H,1-6H2,(H,9,10)

Upstream product

• 33768-74-0 4,5,6,7-tetrahydro-3H-benzofuran-2-one 
• 4354-67-0 2-cyclohexylmalonic acid 
• 4441-63-8 4-cyclohexylbutanoic acid 
• 104543-10-4 2-cyclohexyl-1-nitro-1-(pyridine-2-thiyl)ethane 
• 6051-03-2 hexahydro-3H-benzofuran-2-one 
• 65426-79-1 cyclohexaneacetic acid p-nitrophenyl ester 
• 31151-40-3 2-cyclohexyl-1-diazo-2-ethanone 
• 103-78-6 4-cyclohexyl-butan-2-one 
• 18294-87-6 1-cyclohexenylacetic acid 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 103-82-2 phenylacetic acid 
• 64-19-7 acetic acid 
• 4132-61-0 6-cyclohex-1-enyl-hexanoic acid 
• 6713-49-1 cyclohexyl cyclohexylmethyl ketone 

Downstream Products

• 104437-02-7 4-[6-(2-Cyclohexyl-acetylamino)-indol-1-ylmethyl]-3-methoxy-benzoic acid methyl ester 
• 134458-79-0 (2R,3R,4R,5S)-6-Cyclohexyl-5-(2-cyclohexyl-acetylamino)-3,4-dihydroxy-2-isopropyl-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide 
• 4442-79-9 cyclohexylethan-1-ol 
• 142416-27-1 Cyclohexyl-ethaneperoxoic acid 
• 65842-45-7 S-phenyl 2-cyclohexylethanethioate 
• 378185-92-3 (4R)-4-Benzyl-3-(2-cyclohexylacetyl)-1,3-oxazolan-2-one 
• 854448-82-1 2-cyclohexylpent-4-enoic acid 
• 862898-41-7 N-[2-(2-cyclohexylacetylamino)phenyl]-2,2-diphenylacetamide 
• 862898-48-4 N-[2-(cyclohexylacetylamino)phenyl]-cyclohexylphenylacetamide 

Relevant articles and documents

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Mild and Selective Rhodium-Catalyzed Transfer Hydrogenation of Functionalized Arenes

Diboron-mediated rhodium-catalyzed transfer hydrogenation of functionalized arenes is reported. In addition to good functional group tolerance, the reaction features operational simplicity and controllable chemoselectivity. The general applicability of this procedure is demonstrated by the selective hydrogenation of a range of arenes, including functionalized benzenes, biphenyls, and polyaromatics.

Method for synthesizing cyclohexanecarboxylic acid by catalyzing hydrogenation of benzene rings through rubidium-gallium-loaded catalytic material

The invention relates to the fine chemical engineering field and particularly relates to a method for synthesizing cyclohexanecarboxylic acid by catalyzing hydrogenation of benzene rings through a rubidium-gallium-loaded catalytic material. According to the method, aromatic ring carboxylic acid is catalyzed by virtue of the rubidium-gallium-loaded catalytic material in deionized water and generates selective addition reaction with hydrogen at a low temperature and a relatively low pressure so as to generate cyclohexanecarboxylic acid; the reaction temperature is low, the reaction pressure is lower than that in the prior art, no organic solvent is adopted, the side reactions are few, and the product is conveniently purified, and the method is suitable for industrial production; and the prepared rubidium-gallium-loaded catalytic material can be recycled, is high in catalytic activity and strong in selectivity and is a very promising novel catalytic material.