4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

Base Information

Chemical Name:4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone
CAS No.:1421854-32-1
Molecular Formula:C₂₄H₃₁FO₂Si
Molecular Weight:398.593
Hs Code.:

Synonyms:4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

Chemical Property:

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Technology Process of 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

There total 8 articles about 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421854-31-0
4-(2-fluorophenyl)-4-(4-hydroxyphenyl)cyclohexanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1421854-32-1
4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1421854-29-6
2-(4-(benzyloxy)phenyl)-2-(2-fluorophenyl)acetaldehyde

: 1421854-32-1
4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / tetrahydrofuran; ethanol / 0 - 20 °C

1.2: 0.5 h / 50 °C

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; potassium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1421854-30-9
4-(4-(benzyloxy)phenyl)-4-(2-fluorophenyl)cyclohex-2-enone

: 1421854-32-1
4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; In ethyl acetate; N,N-dimethyl-formamide;