3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine

Base Information

• Chemical Name: 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine
• CAS No.: 1378238-60-8
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 1378238-60-8.mol

Synonyms:3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine

Chemical Property of 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine

There total 18 articles about 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-yltrifluoromethanesulfonate → 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine (1378238-60-8)

Guidance literature:

3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-yltrifluoromethanesulfonate; With Benzophenone imine; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 36h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; water; for 1h; pH=2 - 3;

DOI:10.1016/j.tetlet.2018.12.033

Reference yield: 88.0%

3-methoxy-4-nitro-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene (1378238-59-5) → 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine (1378238-60-8)

Guidance literature:

With acetic acid; zinc; for 2h; Inert atmosphere;

Reference yield: 85.0%

2-methoxy-1-nitro-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol (1378238-58-4) → 3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine (1378238-60-8)

Guidance literature:

With acetic acid; zinc; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.01.007

upstream raw materials:

2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

5-(3'-methoxy-2'-nitrophenyl)pentanoic acid

2-methoxy-1-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

2-methoxy-1-nitro-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol