5-(3'-methoxy-2'-nitrophenyl)pentanoic acid

Base Information

• Chemical Name: 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid
• CAS No.: 1378238-57-3
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 1378238-57-3.mol

Synonyms:5-(3'-methoxy-2'-nitrophenyl)pentanoic acid

Chemical Property of 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid

There total 2 articles about 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-(3'-methoxy-2'-nitrophenyl)pent-4-enoic acid (1378238-56-2) → 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid (1378238-57-3)

Guidance literature:

With cyclohexa-1,4-diene; palladium 10% on activated carbon; In methanol; for 4h; Inert atmosphere;

Reference yield:

3-methoxy 2-nitrobenzaldehyde (53055-05-3) → 5-(3'-methoxy-2'-nitrophenyl)pentanoic acid (1378238-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C

2.1: cyclohexa-1,4-diene / palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere

With cyclohexa-1,4-diene; potassium tert-butylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1.1: Wittig Reaction;

Reference yield: 85.0%

5-(3'-methoxy-2'-nitrophenyl)pentanoic acid (1378238-57-3) → 2-methoxy-1-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one (71089-19-5)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 20 ℃; for 12h; Inert atmosphere;

upstream raw materials:

3-methoxy 2-nitrobenzaldehyde

5-(3'-methoxy-2'-nitrophenyl)pent-4-enoic acid

Downstream raw materials:

2-methoxy-1-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

2-methoxy-1-nitro-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol

3-methoxy-4-nitro-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene

3-methoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-amine