beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide

Base Information

Chemical Name:beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide
CAS No.:115560-39-9
Molecular Formula:C₁₄H₂₁NO₄
Molecular Weight:267.325
Hs Code.:
DSSTox Substance ID:DTXSID201177793

Synonyms:DTXSID201177793;beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide;115560-39-9

Suppliers and Price of beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:267.14705815
Heavy Atom Count:19
Complexity:283

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)OCOC)C(CC(=O)N(C)C)O

Technology Process of beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide

There total 3 articles about beta-Hydroxy-2-(methoxymethoxy)-N,N,5-trimethylbenzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 55359-68-7
2-(methoxymethoxy)-5-methylbenzaldehyde

: α-lithio-N,N-dimethylacetamide

: 115560-39-9
3-Hydroxy-3-(2-methoxymethoxy-5-methyl-phenyl)-N,N-dimethyl-propionamide

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/S0040-4039(00)61828-2

Reference yield:

: 106-44-5
p-cresol

: 115560-39-9
3-Hydroxy-3-(2-methoxymethoxy-5-methyl-phenyl)-N,N-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / p-toluenesulfonic acid, 4-A sieves / CH₂Cl₂ / 48 h / Heating

2: 1.) n-butyllithium, TMEDA / 1.) ether, hexane, -20 deg C, 1 h, 2.) 1 h

3: 1.) LDA / 1.) hexane, THF, 15 min, 2.) -78 deg C, 3 h

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; toluene-4-sulfonic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00252a011

Reference yield:

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

: 115560-39-9
3-Hydroxy-3-(2-methoxymethoxy-5-methyl-phenyl)-N,N-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium, TMEDA / 1.) ether, hexane, -20 deg C, 1 h, 2.) 1 h

2: 1.) LDA / 1.) hexane, THF, 15 min, 2.) -78 deg C, 3 h

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide;
DOI:10.1021/jo00252a011